Angiotensinogen Gene Polymorphism Near Transcription Start Site and Blood Pressure
نویسندگان
چکیده
منابع مشابه
Angiotensinogen gene polymorphism near transcription start site and blood pressure: role of a T-to-C transition at intron I.
Molecular variants of the angiotensinogen gene, a key component of the renin-angiotensin system, are considered genetic risk factors for primary hypertension. A relation between the angiotensinogen gene locus and hypertension has been found in whites, Japanese, and African Caribbeans but not in Chinese. The lack of a consistent association between M235T polymorphism at exon 2 and hypertension h...
متن کاملT+31C polymorphism of angiotensinogen gene and nocturnal blood pressure decline: the Ohasama study.
BACKGROUND We assessed the association between several polymorphisms of angiotensinogen gene (AGT) and essential hypertension using ambulatory blood pressure (BP). METHODS We recruited 802 subjects in a rural Japanese community who were aged >40 years and who gave written informed consent for monitoring of their ambulatory BP and genetic analysis (the Ohasama Study). As a polymorphism of AGT,...
متن کاملA polymorphism of the angiotensinogen gene associated with variation in blood pressure in a genetic isolate.
BACKGROUND The Hutterite Brethren are a genetic isolate characterized by high indices of relatedness and a communal agrarian lifestyle. We hypothesized that variation of the angiotensinogen (AGT) and angiotensin-converting enzyme (ACE) genes would be associated with variation in resting blood pressure in this group. We also hypothesized that the association would depend on the sex of the subjec...
متن کاملAngiotensinogen gene-activating elements regulate blood pressure in the brain.
Although the angiotensinogen gene is a possible candidate as a determinant of hypertension, the molecular mechanisms of tissue angiotensinogen gene regulation have yet to be clarified. We identified essential transcription regulators of angiotensinogen production in the central nervous system using synthetic double-stranded oligodeoxynucleotides (ODNs) as "decoy" cis elements to block the bindi...
متن کاملTranscription start site-associated small RNAs in the PTEN gene.
The PTEN gene is inactivated in various cancers. PTEN has a pseudogene in the human genome, PTENpg1, which up-regulates PTEN expression by acting as a miRNA sponge. Interestingly, one of the antisense RNAs from the PTENpg1 locus, PTENpg1 asRNA α, is found to epigenetically down-regulate PTEN transcription by recruitment of EZH2 and DNMT3a to the PTEN promoter in trans (1). In a recent paper in ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Hypertension
سال: 1999
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.34.3.430